Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-40
SponsorCornell University
About this trial
The FeMicrobiome study will evaluate gut microbiome features and their relationships with dietary iron absorption in healthy adults. The investigators hypothesize that (1) the gut microbiota can be shaped by the heme and non-heme Fe content of the diet and that (2) this will influence individual variation in dietary Fe absorption.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy adults
Age between 18- 40y
Non-smoking
Not currently taking vitamin, mineral, prebiotic, and probiotic supplements.
Disqualifiers
BMI <18 or > 27 kg/m2,
Age <18 y or > 40y,
Smoking
Pregnancy, lactating
Trial population
120 healthy adults who habitually consume plant-based diets or habitually consume diets containing animal protein
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
The percent of non-heme iron absorption
Percent non-heme iron absorption will be determined by red blood cell iron incorporation of stable 57Fe
Time frame
2-week2
The concentrations of hemoglobin
The concentrations of hemoglobin (d/dL)
Time frame
baseline3
The concentrations of ferritin
The concentrations of ferritin (ug/L)
Time frame
baseline4
Serum transferrin receptor
Serum transferrin receptor in mg/L
Time frame
baselineSponsors and contacts
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Source ClinicalTrials.gov