The aim of this study is to compare the efficacy of intrauterine application of heparin solution to the use of hyaluronic acid barrier gel for the prevention of intrauterine adhesion formation after operative hysteroscopy.
female sex
infertility,
irregular bleeding,
oligo-/amenorrhea,
ongoing pregnancy,
genital cancer,
pelvic inflammatory disease,
excessive uterine bleeding.
Parallel
Heparin solution
Drug3 ml saline solution containing 5000 IU heparin.
Anti-adhesion barrier gel
Drug2 ml biodegradable barrier gel containing sodium hyaluronate (10 mg/ml), sodium chloride (8.5 mg/ml), disodium hydrogen phosphate (0.34mg/ml), sodium dihydrogen phosphate (0.14 mg/ml) and water for injection (QS to weight).
Number of patients with post-operative intrauterine adhesion formation
Incidence and severity of intrauterine adhesions identified at follow-up diagnostic hysteroscopy as assessed according to Valle and Sciarra's classification of intrauterine synaechia
Number of patients with need for subsequent operative hysterectomy
Pathological findings at second-look hysteroscopy taken as indication for successive uterine surgery
Number of patients with persistent irregular menstrual bleeding
Recurring abnormal menstrual cycle patterns identified post initial surgery
Number of patients with fertility improvement
Successful pregnancy post surgical procedure
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