High Flow Nasal Cannula Weaning in Acute Bronchiolitis
ConditionAcute Bronchiolitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-12
SponsorKuopio University Hospital
About this trial
The goal of this clinical study is to compared two different strategies to end high flow nasal cannula treatment in acute bronchiolitis. This study compared the immediate ending of high flow treatment to weaning strategy, in which the flow rate is gradually decreased. The aim is to assess if the immediate ending shortens the hospitalization time and whether it is a safe strategy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Clinically diagnosed acute bronchiolitis
High flow nasal cannula treatment has lasted for at least 12 hours
Measured saturation 95 or more with room air
High flow rate is maximum 2l/kg/min
Disqualifiers
Major congenital anomaly of lungs, hearts or diaphragm
Bacterial pneumonia
Parents do not give consent
Trial design
Design model
Parallel
Treatments tested in this trial
High flow nasal cannula immediate ending
Other interventionHigh flow is immediately ended
High flow nasal cannula weaning
Other interventionHigh flow is gradually weaned by reducing the flow rate
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Immediate endingExperimental treatment 1 intervention
Group B: WeaningActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Hospitalization time from randomization
Time in hours from the randomization to the time the family leaves hospital.
Time frame
One weekSecondary outcomes
1
Treatment failures
Need to restart the high flow therapy
Time frame
One week2
Readmission rate
Need for readmission
Time frame
Seven days from discharge3
Overall hospitalization time
The overall time, which includes the time interval prior to randomization
Time frame
One weekSponsors and contacts
Click on the lead sponsor to view all of their trials.
Kuopio University Hospital
Lead sponsor
Central Finland Hospital District
Collaborator
Mikkeli Central Hospital
Collaborator
Siun sote
Collaborator
Source ClinicalTrials.gov