High Frame Rate Ultrasound in Heart Disease Assessment
ConditionCoronary Artery Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorLondon North West Healthcare NHS Trust
About this trial
The study will compare standard ultrasound images to high frame rate ultrasound images in patients with heart disease or with a low risk of heart disease to see if a higher frame rate of ultrasound adds to the information obtained from standard ultrasound.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Ability to give informed consent
age ≥18years and
confirmed inducible wall motion / perfusion abnormality on previous stress echocardiogram
known coronary artery disease - defined by presence of flow-limiting coronary stenosis(>70% diameter stenosis) on coronary angiography.
Disqualifiers
Inability to undertake pharmacological stress, ie previously known intolerance to dipyridamole;
Moderate or Severe aortic or mitral regurgitation or severe mitral stenosis;
Significant pulmonary disease like severe COPD or pulmonary fibrosis;
Atrial fibrillation;
Trial population
25 patients will be recruited over 12 months. 5 of these patients will be at low high of having coronary artery disease and 20 at high risk of coronary artery disease. patients will be recruited from those referred for clinical stress stress echocardiography.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Standard echocardiography
Diagnostic testPatients will undergo standard echocardiography, with and without contrast
High frame rate echocardiography
Other interventionFollowing standard echocardiography, the test is repeated using high frame rate ultrasound
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Agreement between HFR ultrasound and standard ultrasound.
Demonstration that there is at least 80% agreement between HFR ultrasound techniques and standard techniques. Expressed as as a percentage of the recorded images.
Time frame
At 1 yearSponsors and contacts
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Source ClinicalTrials.gov