Diabetes/ prediabetes is a substantial problem in India not only because it itself can be associated with morbidities such as coronary artery disease but also because it is a point of importance for the prevention of other diseases. It is not clear if a high protein calorie diet in the Indian population associated with a heightened tendency for prediabetes, metabolic syndrome, atherosclerosis and dysmetabolic state etc. could, besides lifestyle factors, be related to diet, or interaction between the two. The analysis of whole blood transcriptomes and plasma metabolomics profiles may be a potentially useful tool for the assessment of metabolic health status. The proposed study is the first to perform a detailed gene expression profiling with the use of next-generation sequencing technology to assess the differences in molecular mechanisms in the peripheral blood of subjects with prediabetes.
None
Acute infections and advanced end-organ damage.
History of hepatitis or pancreatitis, abnormal liver and renal function tests.
Recent (<3 months) changes in weight (≥5%) and/or weight changing medications.
Subjects with metallic implants, pacemaker leads, radioactive seeds or surgical staples in the body.
Parallel
Intervention
Other interventionhigh protein diet (carbohydrates 45%, protein 29%, and fat 26%) over 8-week periods.
Body Mass Index
BMI will be calculated by using formula weight (Kg)/height (m2).
Body Fat
Body estimations will be done by DEXA Scan
Liver Fat
Liver fat will be done by MRI Scan
Next Generation sequencing
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
