High Resolution Anuscopy Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversitair Ziekenhuis Brussel
About this trial
The majority of anal squamous cell carcinomas (SCC) stem from infection with high-risk human papillomavirus (HPV). Anal SCC is rare among the general population but affects several populations disproportionately.
High-risk groups are screened through anal swabs for anal cytology and detection of high risk human papillomavirus (HR HPV). HRA referral is recommended for individuals with abnormal cytology.
HRA represents the only method to identify precancerous lesions of the anal canal, with only few specialists knowledgeable about it.
At UZ Brussel, the investigators collected a wealth of data about HPV infection and its association with anal pathology. By establishing a comprehensive study, the investigators can delve into this data with specific research questions, conducting valuable research to provide answers to pressing clinical questions and contribute to advancements in medical understanding and treatment.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
All patients who have undergone HRA and all future patients referred for HRA in UZ Brussel
18 years or older
Understands and able to speak and write in French, Dutch or English
Disqualifiers
None
Trial population
All patients who underwent or will undergo High Resolution Anoscopy in UZ Brussel after Informed Consent
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
HRA
Other interventionHigh resolution anoscopy to help evaluate anal conditions such as precancerous lesions
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
comparison of the prevalence of precancerous lesions in men who have sex with men using PrEP or are HIV positive Men
Time frame
Through study completion, on average 5 years2
Exploration of associations between abnormal histology and patient characteristics
Time frame
Through study completion, on average 5 years3
comparison of the prevalence of precancerous lesions in different groups
Time frame
Through study completion, on average 5 years4
to delineate unique features associated with HSIL in each risk group by linking patterns or characteristics
such as verrucous aspects, coarse punctuation, mosaic patterns, flat morphology, and fragility
Time frame
Through study completion, on average 5 yearsSponsors and contacts
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Source ClinicalTrials.gov