HIPEC Surgery and Hemodynamics
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMiray Gözde Özdemir
About this trial
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) involves the intraoperative administration of heated chemotherapeutic agents into the abdominal cavity following cytoreductive surgery (CRS). The increasing use of CRS combined with HIPEC has introduced certain procedural and physiological considerations that distinguish it from other surgical interventions, posing unique challenges for researchers and clinicians alike.
Despite advancements in surgical and anesthetic techniques, this combined approach is frequently associated with significant hemodynamic instability, coagulation abnormalities, respiratory complications, and nutritional imbalances.
The study aims to contribute to the existing body of knowledge by examining the physiological alterations induced by HIPEC, thereby offering practical insights and guidance for investigators involved in the management and study of this complex therapeutic modality.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
≥18 years old Patients planned to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
ASA II-III-IV physical class
Disqualifiers
<18 years
Emergency cases
Trial population
Patients aged 18 years and older who are scheduled for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
15 Participants
are grouped into 1 trial groupGroup A: Group 1
Trial outcomes
Primary outcomes
1
physiological parameter ; heart rate
HIPEC is usually the application of chemotherapy that lasts between 45 and 90 minutes after the end of cytoreductive surgery. During HIPEC application (45-90 minutes), Heart rate: will be recorded every 10 minutes as beats / minute.
Time frame
Intraoperatively2
physiological parameter; systolic/diastolic blood pressure
Systolic/diastolic blood pressure will be recorded in mmHg every 10 minutes.
Time frame
Intraoperatively3
physiological parameter; SpO2
SpO2 will be recorded as percent every 10 minutes.
Time frame
Intraoperatively4
anesthesia device measurement parameter; EtCo2
EtCo2 will be recorded every 10 minutes as mmHg.
Time frame
IntraoperativelySecondary outcomes
1
Preoperative data
In the preoperative period, the patient's additional diseases, medications used, surgical history, and ASA score will be recorded.
Time frame
24 hours before surgery2
Postoperative data
The patient's general condition before discharge, and any complications related to surgery will be recorded.
Time frame
24 hours after surgerySponsors and contacts
Click on the lead sponsor to view all of their trials.
Miray Gözde Özdemir
Lead sponsor
Ankara Etlik City Hospital
Sponsor institution
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: