Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorShanghai University of Sport

About this trial

This trial aims to investigate whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory function and dual-task postural control among older adults with mild cognitive impairment (MCI). The primary research questions to be addressed are as follows:

* Can 40 Hz hippocampal temporal interference stimulation boost memory test performance in older adults with MCI? * Can 40 Hz hippocampal temporal interference stimulation improve walking and balance ability under dual-task conditions in older adults with MCI? Researchers will compare active 40 Hz hippocampal temporal interference stimulation against sham stimulation to identify whether this intervention yields positive immediate effects on memory function and dual-task postural control.

Participants will be required to:

* Attend three laboratory visits over approximately three weeks, and receive one session of active stimulation and one session of sham stimulation in random order, with an interval of at least seven days between the two stimulation visits; * Complete memory and motor function assessments before and after each stimulation session; * Undergo functional magnetic resonance imaging (fMRI) scans to detect changes in brain activity.

Eligibility criteria

Qualifiers

Aged 65 years or older;

Presence of subjective memory complaints;

Objective cognitive impairment: screened using the Montreal Cognitive Assessment-Bejingversion (MoCA-BJ). The MoCA-BJ total score is 30 points. For individuals with <12 years ofeducation, 1 point is added to the raw total score (corrected total score capped at 30 points); acorrected total score <26 points indicates risk of cognitive impairment;

Clinical Dementia Rating (CDR) score of 0.5;

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Temporal Interference Stimulation

Treatment groups

21 Participants
are divided into 2 treatment groups

Sponsors and collaborators