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Hippocampal Volume and Memory Functions in Aneurysmal Subarachnoid Hemorrhage

ConditionsNeurologic DisorderSubarachnoid Hemorrhage, Aneurysmal
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorBDH-Klinik Hessisch Oldendorf

About this trial

Neuropsychological and functional long-term consequences of subarachnoid hemorrhages (SAH) represent a great challenge, since sometimes considerable cognitive deficits occur without evidence of substantial brain damage. In this study, we want to examine if the frequently observed memory deficits are associated with hippocampal atrophy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

neurological rehabilitation patients in phase B - D

at minimum eight weeks after disease onset

aneurysmal subarachnoid hemorrhage (Hunt & Hess grade I or II)

written consent from the patient's legal representative

Disqualifiers

insufficient cardiorespiratory stability

previous brain damage

mental disorders (dementia, depression)

colonization with multi-resistant pathogens

Trial population

neurological rehabilitation patients with aneurysmal subarachnoid hemorrhage (Hunt \& Hess grade I or II)

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Neuropsychological assessment and structural MRI

    Diagnostic test

    Complex neuropsychological assessment testing attentional and memory functions. Additionally, a structural MRI is measured.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Experimental group1 intervention
Group B: Control group1 intervention

Trial outcomes

Primary outcomes

1

Changed hippocampal volume in aSAB

Hypothesis: patients have smaller hippocampal volume than healthy control subjects. For the hippocampal volume a structural MRI scan (3D-MPRAGE) is obtained

Time frame
2 weeks

Secondary outcomes

1

Changed memory function in aSAB

Hypothesis: patients have lower scores in the Visual and Verbal memory test (VVM) than healthy control subjects.

Time frame
2 weeks
2

Influence of the type of therapy on the hippocampal volume

Hypothesis: hippocampal volumes differ between aSAH patients with surgical or endovascular treatment.

Time frame
2 weeks
3

Influence of the lesion site on the hippocampal volume

Hypothesis: there are no differences between ispi- and contralateral hippocampal volumes

Time frame
2 weeks
4

Interrater reliability

Hypothesis: It is expected that there will be no difference in the ratings of hippocampal volume between two independent raters.

Time frame
2 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

BDH-Klinik Hessisch Oldendorf

Lead sponsor

Source ClinicalTrials.gov
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