Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis
ConditionAcute Kidney Injury
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversität des Saarlandes
About this trial
Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.
Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.
This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients treated on the intensive care units of Saarland University Hospital.
Disqualifiers
Patients on renal replacement treatment before admission to the intensive care unit.
Patients with chronic kidney disease stage CKD G3b or below.
Known kidney disease.
Kidney transplantation.
Trial population
Patients on intensive care units of the Saarland University Hospital.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
DKK-3
Diagnostic testDKK-3-Urine measurement
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Urinary dickkopf-3
Urinary dickkopf-3
Time frame
Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.2
Estimated Glomerula Filtration Rate
Estimated Glomerula Filtration Rate by CKD-EPI-formula.
Time frame
Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.Secondary outcomes
1
Mortality
Number of patients who die during the observational period.
Time frame
Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.2
End Stage Renal Disease
Number of patients with initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation).
Time frame
Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.3
Length of renal replacement therapy
Length of time patients receive renal replacement therapy for chronic kidney injury.
Time frame
During the ICU stay.Sponsors and contacts
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Source ClinicalTrials.gov