Home-based Vision Rehabilitation Guided by Brain Imaging

ConditionsVisual Field Defect Stroke Hemianopia Homonymous Quadrantanopia Cortical Blindness Visual Field Defect, Peripheral Visual Field Loss Traumatic Brain Injury Brain Tumor

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorGeorgetown University

About this trial

The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.

Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

At least 18 years of age.

Capable of providing informed consent and complying with study procedures.

Unilateral or bilateral focal brain damage causing visual field loss.

At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.

Disqualifiers

Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.

Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.

Ocular disease or disorder.

Trial design

Design model

Crossover

Treatments tested in this trial

High-level perceptual learning-based training
Behavioral
Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing
Low-level perceptual learning-based training
Behavioral
behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing

Treatment groups

100 Participants

are divided into 2 treatment groups

Group A: Perceptual learning-based training using high-level visual stimuliExperimental treatment 1 intervention

Group B: Perceptual learning-based training using low-level visual stimuliActive comparator 1 intervention

Trial outcomes

Primary outcomes

Change in high-level perceptual discrimination performance

Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

Time frame

Week 2-4 or Week 7-9 of the study (depending on the order)

Change in low-level perceptual discrimination performance

Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

Time frame

Week 2-4 or Week 7-9 of the study (depending on the order)

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Georgetown University

Lead sponsor

American Heart Association

Collaborator

Source ClinicalTrials.gov

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