Home Blood Pressure Variability and Its Link to Arteriosclerosis and Metabolic Dysfunction in Hypertensive Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age19+
SponsorKorea University Anam Hospital
About this trial
This observational study investigates the correlation between home blood pressure variability (BPV) and arteriosclerosis, alongside metabolic indicators, in hypertensive patients over a three-year period. The research specifically focuses on the predictive value of home BPV for major adverse cardiovascular events (MACE) including myocardial infarction, stroke, and heart failure hospitalizations. Utilizing a mobile application called Healthscan for daily BP monitoring, the study aims to enhance the understanding of how BPV impacts cardiovascular and metabolic health in a real-world setting.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 19 years or older.
Diagnosed with hypertension.
Regular use of antihypertensive medication for at least two years.
Access to a home blood pressure monitor.
Disqualifiers
None
Trial population
The study population consists of adult hypertensive patients from various clinical settings, including community clinics and academic hospitals. Participants are broadly recruited to reflect a diverse population regarding age, sex, and severity of hypertension.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Healthscan App
BehavioralParticipants will use the Healthscan mobile application to monitor and record their daily blood pressure at home. The app allows participants to enter their BP measurements, which are then used to calculate blood pressure variability (BPV). The app's use is intended as a non-invasive, practical tool for patient self-management and longitudinal health monitoring in hypertensive individuals.
Treatment groups
4,188 Participants
are divided into 1 treatment groupGroup A: Home BP Monitoring Cohort1 intervention
Trial outcomes
Primary outcomes
1
Correlation between Home Blood Pressure Variability and Pulse Wave Velocity
Measure the strength and nature of the relationship between variability in home-monitored blood pressure and pulse wave velocity, a primary indicator of arteriosclerosis.
Time frame
1 yearSecondary outcomes
1
Association between Home BPV and Additional Arteriosclerosis Indicators
Assess the correlation of home BPV with other arteriosclerosis indicators including ankle-brachial index, central systolic blood pressure, and second systolic peak blood pressure.
Time frame
1 year2
Correlation between Home BPV and Metabolic Indicators
Evaluate the association between home BPV and metabolic health indicators such as fasting glucose levels and lipid profiles (total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides).
Time frame
1 yearOther outcomes
1
Incidence of Major Adverse Cardiovascular Events (MACE)
Monitor and record the incidence of major adverse cardiovascular events including myocardial infarction, stroke, and heart failure hospitalizations among study participants.
Time frame
3 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Korea University Anam Hospital
Lead sponsor
Korean Society of Hypertension
Collaborator
Source ClinicalTrials.gov