Home Exercise for Individuals With Neurodegenerative Disease

ConditionsNeurodegenerative Diseases Leukodystrophy Ataxia LBSL Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation Cerebellar Ataxia Adrenomyeloneuropathy

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age5-75

SponsorHugo W. Moser Research Institute at Kennedy Krieger, Inc.

About this trial

The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing.

The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis.

The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis.

For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia.

Disqualifiers

None

Trial design

Design model

Single group

Treatments tested in this trial

Home exercise
Behavioral
Exercise to address limitations impacting walking

Treatment groups

30 Participants

are divided into 1 treatment group

Group A: Home exerciseExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Change in NeuroQOL lower extremity

Patient reported outcome

Time frame

baseline 12 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Lead sponsor

Source ClinicalTrials.gov

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