About this trial
Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes.
Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.
Eligibility criteria
Qualifiers
Adult (≥18years old at the time of giving consent)
Consented and listed for bilateral tonsillectomy or adenotonsillectomy
Tonsillectomy performed within the trial study period
Disqualifiers
Any concurrent Head & Neck (H&N) malignancy
Unilateral tonsillectomy
Pregnancy
Concurrent pharyngeal or upper aerodigestive tract biopsy
Trial design
Treatments tested in this trial
- Manuka honey MGO 1000
- Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring