Health TrialsbyHealthPanel

Hop Compounds on the Immune System in Overweight People

ConditionInflammatory Response
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity of Vienna

About this trial

The aim of the present study is to determine the effect of Iso-alpha Acids and Xanthohumol from hops on the immune response in overweight participants.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

BMI 25 - 29,9 kg/m²

pre-diabetes (fasting blood glucose 100-125 mg/dL),

fatty liver (grade 1-3),

high-normal blood pressure to mild hypertension (grade 1, systolic 140-159 mmHg)

Disqualifiers

History of diseases that could falsify the study results

inflammatory bowel diseases

malignant diseases of the gastrointestinal tract

food allergies

Trial design

Design model

Crossover

Treatments tested in this trial

  • Xanthohumol

    Dietary supplement

    Participants receive a study drink supplemented with Xanthohumol (0 mg = Placebo or 0.75 mg soluble Xanthohumol)

  • Iso-alpha Acids

    Dietary supplement

    Participants receive a study drink supplemented with Iso-alpha Acids (0 mg = Placebo or 45 mg Iso-alpha Acids)

  • Xanthohumol + Iso-alpha Acids

    Dietary supplement

    Participants receive a study drink supplemented with Xanthohumol and Iso-alpha Acids (0 mg = Placebo or 0.75 mg + 45 mg soluble Xanthohumol + Iso-alpha Acids)

Treatment groups

24 Participants
are divided into 3 treatment groups
Group A: XanthohumolExperimental treatment 1 intervention
Group B: Iso-alpha AcidsExperimental treatment 1 intervention
Group C: Xanthohumol + Iso-alpha AcidsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Changes in parameters of immune response

Changes in concentration of interleukin 6 (ng/ml) in cell culture supernatant of stimulated cells

Time frame
6 hours
2

Changes in parameters of immune response

Changes in concentrations of interleukin 1 beta (ng/ml) in cell culture supernatant of stimulated cells

Time frame
6 hours
3

Changes in parameters of immune response

Changes in concentration of tumor necrosis factor alpha (ng/ml) in cell culture supernatant of stimulated cells

Time frame
6 hours

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Vienna

Lead sponsor

Source ClinicalTrials.gov
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