How Differences in the Composition of Microorganisms in the Soil Affect the Microorganisms in the Human Gut, Through the Vegetables That Grow in it: a Process Pilot Study With Healthy Participants

ConditionPilot Study
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorLeiden University Medical Center

About this trial

There are two objectives for this clinical trial. The first is to test whether, with the current logistics and study setup it is possible to perform the study well and see where there might be bottlenecks we couldn't predict. The second objective is to investigate the relation between the composition of the microorganisms in the soil, the crops that grow in that soil, and the human gut. During the study participants will drink three vegetable smoothies a day, for two periods of one week. The only difference between the two periods is whether the vegetables come from a farm with a low diversity of microorganisms in the soil or a high diversity. Participants will be asked to give blood samples and turn in fecal samples before and after each period.

Eligibility criteria

Qualifiers

Aged 18 to 70 years

Written informed consent

Inhabitant of Leiden

Disqualifiers

Any documented causes of chronic disease

Suspicion of or present excessive alcohol use defined as >2 units/day (>14/week)

Recent use (<3 months) of antibiotics

Any known food allergy or restriction, or following a vegan/vegetarian diet

Trial design

Treatments tested in this trial

  • Low diversity vegetable smoothie
  • High diversity vegetable smoothie

Treatment groups

10 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Leiden University Medical Center

Lead sponsor

Maastricht University

Collaborator