The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.
Age 18-40 years
Ability to read, understand, and provide written informed consent in German
Proficiency in German
Able to give blood samples (no blood- or needle-related phobia)
Any current instable medical or neurological condition
Any clinically significant psychiatric disorder (i.e., psychotic and stress-related disorders) including a diagnosis of substance use disorder (defined in DSM-5 terms as Moderate or Severe). Participants will be screened using the Structured Clinical Interview - SCID for DSM-5). If indication is obtained that a clinically significant psychiatric disorder may be present, a full SCID will be carried out by appropriately trained staff.
Significant adverse reaction to prior opioid or paracetamol exposure
Reporting any illegal drug use >15 life-time occasions and regular drug use during the last three months incl. the test period (except for nicotine and alcohol)
Sara L. Kroll
Lead sponsor
Psychiatric University Hospital, Zurich
Sponsor institution