How Wall Squat Exercise Affects Blood Pressure in People With High Blood Pressure and Treated Sleep Apnea (WALLPRESS)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorAveiro University
About this trial
This study will look at whether a simple exercise called the isometric wall squat can help lower blood pressure in adults who have both hypertension and obstructive sleep apnoea treated with CPAP. Obstructive sleep apnoea is a condition in which breathing repeatedly stops or becomes shallow during sleep, and it is closely linked to high blood pressure. Although CPAP helps treat sleep apnoea, it usually lowers blood pressure only a little, so additional non-drug strategies may be useful.
The study will compare two situations in the same participants: one session of wall squat exercise and one non-exercise control session. Each participant will take part in both sessions, but the order will be random. This design helps the researchers compare blood pressure changes more fairly within the same person.
Participants will first attend a familiarization session, where the study procedures will be explained and the exercise intensity will be checked. After that, they will complete the two study sessions at home, during their usual CPAP treatment visits. The sessions will be separated by at least 48 hours and completed within one week. Both sessions will be scheduled at the same time of day to reduce the effect of normal daily changes in blood pressure.
The main result the researchers will measure is the average systolic blood pressure during the 12 hours after each session, using ambulatory blood pressure monitoring. This means blood pressure will be measured over time while the participant goes about normal daily activities. The researchers want to find out whether a single session of wall squat exercise produces a greater blood pressure reduction than simply resting without exercise.
This study may help improve understanding of whether isometric exercise can be a practical, low-cost, home-based option to support blood pressure control in people with hypertension and CPAP-treated obstructive sleep apnoea.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
18-80 years old.
Diagnosis of hypertension and OSA confirmed by polysomnography or respiratory sleep study.
Apnea-Hypopnea Index (AHI) of at least 15 events per hour.
Treatment with CPAP for at least 3 months.
Disqualifiers
Mean CPAP adherence <4 hours/night over the last month, documented by device download.
Heart failure.
Peripheral artery disease.
Atrial fibrillation.
Trial design
Design model
Crossover
Treatments tested in this trial
Isometric Wall Squat
Other intervention4x2-min isometric wall squat contractions separated by 2-min rest periods plus standard drug therapy
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: Isometric Wall SquatExperimental treatment 1 intervention
Group B: ControlNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
12-hour systolic blood pressure
Systolic blood pressure measured by ambulatory blood pressure monitoring every 30 minutes for 12 hours after the exercise or control session
Time frame
During the 12 hours following the exercise or control sessionSecondary outcomes
1
12-hour diastolic blood pressure
Diastolic blood pressure measured by ambulatory blood pressure monitoring every 30 minutes for 12 hours after the exercise or control session
Time frame
During the 12 hours following the exercise or control session2
Short-term blood pressure variability
Standard deviation of ambulatory readings over 12 hours post-session
Time frame
During the 12 hours following the exercise or control session3
Pulse pressure
Mean difference between systolic and diastolic ambulatory blood pressure during the 12 hours after the exercise or control session
Time frame
During the 12 hours following the exercise or control sessionOther outcomes
1
Adverse events associated with the isometric wall squat exercise session.
Number and type of adverse events (e.g., skin irritation, limb discomfort, cramps, delayed onset muscle soreness) occurring during and/or after the isometric exercise session, classified by severity (mild, moderate, severe), relationship to the intervention (unrelated to definitely related), and type of event
Time frame
From during the session to 72 hours after the exercise sessionSponsors and contacts
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Source ClinicalTrials.gov