The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life and their interaction with the host on maternal-offspring health consequences in later life in the born in Guangzhou cohort study in China. Identification of the effect of microbiota in early life, as well as environmental factors and microbe-host interaction, will lead to a better understanding of disease pathogenesis and provide a foundation for targeted mechanistic investigation into the consequences of microbial-host crosstalk for long-term health. It also can result in new strategies to predict and prevent diseases in later life.
None
None
Pregnant women attending their first routine antenatal examinations (usually around week 16) and their partners and offsrping
Cohort
Prospective
No intervention
Other interventionNo intervention
Numbers of participants with Childhood diseases. Including:
Obesity，asthma，allergic diseases，Delayed neural development，type 1 diabetes，maturity-onset diabetes of the young（MODY), hypertension
Numbers of participants with maternal diseases. Including:
Obesity，asthma，allergic diseases，type 1 diabetes，type 2 diabetes, hypertension , cardiovascular diseases，and obstetric complications，including gestational diabetes，pregnancy induced hypertension, ect.
Neurodevelopment during early childhood
Including adaptive, gross motor, fine motor,language,and social function; assessed using Gesell Developmental Schedules
Neurodevelopment during early childhood
Including adaptive, gross motor, fine motor,language,and social function; assessed using Ages and Stages Questionnaire
Neurodevelopment during preschool age
Including solving skills, pattern perception, and logical thinking；assessed using Raven's Standard Progressive Matrices
Neurodevelopment during preschool age
Including solving skills, pattern perception, and logical thinking；assessed using Peabody Picture Vocabulary Test
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