Human Sinonasal Mucosa Heterogeneity Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorFirst Affiliated Hospital, Sun Yat-Sen University
About this trial
This observational study aims to better understand how the lining of the nose and sinuses differs across different sinonasal sites in humans, including participants with and without sinonasal inflammatory disease. Mucosal tissue samples will be collected from participants who are undergoing clinically indicated sinonasal surgery. The study will compare tissue structure, gene expression, protein expression, and immune cell composition among different regions of the sinonasal mucosa.
By studying these differences, researchers hope to identify site-specific features of human sinonasal mucosa and improve understanding of normal and disease-related changes in the nose and sinuses. This study does not assign participants to any treatment or intervention. The findings may provide a foundation for future research on chronic rhinosinusitis, nasal polyps, and other sinonasal diseases.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 18 years or older.
Scheduled for clinically indicated sinonasal surgery.
Sinonasal mucosal tissue can be collected during surgery without significant additional risk.
Able and willing to provide written informed consent.
Disqualifiers
Unable or unwilling to provide informed consent.
Younger than 18 years of age.
Tissue collection may interfere with standard care or increase surgical risk.
History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa.
Trial population
The study population will include adult participants undergoing clinically indicated sinonasal surgery. Sinonasal mucosal tissue samples may be collected from different anatomical sites of the nasal cavity and paranasal sinuses when available during the planned surgical procedure. Participants may include individuals with sinonasal inflammatory disease as well as individuals undergoing surgery for non-inflammatory sinonasal conditions, depending on clinical availability and protocol requirements. No study-specific treatment or intervention will be assigned.
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
100 Participants
are grouped into 2 trial groupsGroup A: healthy control
Group B: CRSwNP
Trial outcomes
Primary outcomes
1
Site-Specific Heterogeneity of Human Sinonasal Mucosa
Differences in histological features, gene expression patterns, protein expression profiles, and immune cell composition will be compared among mucosal tissue samples collected from different anatomical sites of the human sinonasal tract. These analyses will be used to characterize site-specific biological features and support construction of a human sinonasal mucosal spatial atlas.
Time frame
BaselineSponsors and contacts
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Source ClinicalTrials.gov