Hydrogen-Rich Water and Resting Metabolism in Young Adults
ConditionHealthy Subjects or Volunteers
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Novi Sad
About this trial
The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The study aims to assess whether acute HRW intake can modulate metabolic rate and fuel preference at rest, and to explore inter-individual variability in response.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Aged 18-35 years
BMI between 18.5 and 25.0 kg/m²
Apparently healthy, with no history of chronic disease
Non-smoker, not currently using nicotine-containing products
Disqualifiers
Diagnosed metabolic, cardiovascular, respiratory, gastrointestinal, or endocrine disorders
Use of dietary supplements or medications affecting metabolism (within the past 2 weeks)
Allergy or intolerance to components of the hydrogen or placebo beverages
Pregnant or lactating
Trial design
Design model
Crossover
Treatments tested in this trial
Molecular Hydrogen
Dietary supplementParticipants in this arm will consume a single 250 mL dose of hydrogen-rich water containing approximately 1.6-2.0 ppm of dissolved molecular hydrogen (H₂), The HRW will be ingested following an overnight fast, and resting metabolism will be measured approximately 30-60 minutes post-consumption using indirect calorimetry.
Placebo Comparator
Dietary supplementNon-hydrogen-producing tablets, identical in appearance and taste to the active supplement
Treatment groups
24 Participants
are divided into 2 treatment groupsGroup A: ARM1: 250 ml of Hydrogen Rich WaterExperimental treatment 1 intervention
Group B: ARM 2: 250 ml of Placebo Water (Non-hydrogen-producing tablets)Placebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Resting Energy Expenditure (REE)
The measurements will be obtained during each study visit. Since this is an interventional study assessing the acute effects of molecular hydrogen, measurements will be collected three times: At baseline, without any intervention (pre-familiarization), After a single dose of molecular hydrogen, and After placebo administration. The period between each intervention will be seven days, serving as a washout period to prevent carry-over effects. All participants will be instructed to maintain their regular diet and to avoid alcohol, caffeine-containing beverages, and strenuous physical activity for at least 24 hours prior to each visit. Measure Type: Continuous (kcal/day) Method: Indirect calorimetry Description: To assess the effect of acute ingestion of hydrogen-rich water versus placebo on resting energy expenditure in healthy young adults.
Time frame
Participants will attend three study visits, with each intervention separated by a 7-day washout period to minimize carry-over effects. During each visit, measurements will be conducted approximately 30-60 minutes post-intervention.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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