Iatrogenic Effects of Treatment for Childhood Cancer Constitution of a Biological Samples Bank

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorGustave Roussy, Cancer Campus, Grand Paris

About this trial

The constitution of a biological samples bank, attached to epidemiological studies Cohort F-CCSS on iatrogenic effects of treatment of childhood cancer, will identify genetic variants that can modulate the iatrogenic risks of these treatments. The main objective is to provide a biological samples bank to consider, besides the carcinogenic risks, the risk of other iatrogenic diseases in these children, in particular cardiac, cerebrovascular, lung, bone and kidney. These conditions can be very incapacitating and in some cases, fatal. Their impact, however, is poorly estimated as occurring in adulthood, they are rarely made in relation to the treatment received in childhood. The overall project is expected to eventually better define the iatrogenic effects prevention strategies for cancer treatment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients treated for a first cancer in childhood

Adult patients

Signed informed consent

Patient insured or enjoying a social security scheme

Disqualifiers

Minor patients

Under legal protection measure patients

Refusal of consent

Trial population

Patients treated for a paediatric malignancies before the year 2000 having survived two years after treatment of solid tumor diagnosed before 18 years old

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • saliva samples

    Procedure/Surgery
  • blood samples

    Procedure/Surgery

Treatment groups

10,000 Participants
are divided into 1 treatment group
Group A: Patients treated for cancer in childhood2 interventions

Trial outcomes

Primary outcomes

1

Study of genetic factors who might lead to secondary iatrogenic pathology due to treatment of a childhood cancer

Time frame
From enrollment to the end of study at 15 years

Secondary outcomes

Other outcomes

Sponsors and contacts

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