When children have surgery, anaesthetists carefully monitor the depth of anaesthesia by using sensors on the forehead that measure brain activity, also known as processed electroencephalogram (pEEG). These monitors are routinely used in paediatric anaesthesia; however, investigators do not know if they work accurately in babies and young children with seizure disorders or on anti-seizure medications.
Children with developmental and epileptic encephalopathies may need anaesthesia for tests or procedures. It is important that their treating doctors understand whether these monitors truly reflect how awake or asleep the children are. This study aims to compare a child's electrical brain activity using two commonly used devices in paediatric anaesthesia with the conventional 21-lead EEG patterns in children with seizure disorders. The results of this research may help improve the safety and perioperative care of children with seizure disorders who require general anaesthesia in the future.
Children (<16 years old) with a confirmed diagnosis of early onset EE or DEE due to any cause (prior to age 2 years).
Language barriers impeding data collection
Department for Child Protection and Family Support is involved in the care of the child.
20 eligible patients identified by the neurology department at Perth Children's Hospital and 20 eligible patients identified by the neurology department at Hospital das Clinicas HCFMUSP, Faculdade de Medicina, will be approached for the study.
Cohort
Prospective
Monitoring of patients using electroencephalogram, a Bispectral Index (BIS) and Sedline monitors.
Diagnostic testThis is an observational study of children under 16 years of age, who will be fitted with a 21-lead EEG and then, in consecutive random order, a BIS or Sedline monitor with measurements taken for 30 minutes with each monitor, 60 min in total. This will allow pEEG data to be measured against a corresponding continuous EEG. The depth of anaesthesia monitors used are Bispectral Index (BIS, Medtronic, Minneapolis, Minnesota, USA) and Sedline (Masimo, Irvine, California, USA).
Compare pEEG values in awake patients with developmental and epileptic encephalopathies
pEEG will be measured using Sedline and BIS monitors alongside standard 21-lead EEG.
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Telethon Kids Institute
Lead sponsor
Child and Adolescent Health Service - Perth
Collaborator
Feculdade de Medicina da Universidade de Sao Paulo - Brasil
Collaborator
University of Sao Paulo General Hospital
Collaborator
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