In this project the investigators aim to identify new biological markers by characterizing the response/inflammation associated with the development and progression of M. abscessus lung disease in patients suffering from cystic fibrosis with the aim of increasing current knowledge available on the development and progression of lung disease.
Patients with a certain diagnosis of cystic fibrosis and visited during normal clinical practice, in accordance with the standard operating procedures in force at the Centres.
Both sexes
Age >18 years
Obtaining informed consent for patients (based on the procedures established by the protocol).
Patients unable to understand the instructions and information provided and be able to adequately accept the study methods.
Patients with cystic fibrosis
Case-control
Cross-sectional
Luminex; scRNAsec
Other interventionEvaluation of specific cell populations associated with development of M. abscessus lung disease; evaluation of circulating factors related to immunoresponses
profile of specific cell populations and expression markers to determine the development and progression of M. abscessus lung disease in patients with CF
Evaluate the correlation between early alterations in the profile of specific cell populations or expression markers or soluble immunity activation proteins, considering in particular the development and progression of M. abscessus lung disease in patients with cystic fibrosis
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Ospedale San Raffaele
Lead sponsor
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Collaborator
