The study in question is an observational study that aims to identify new non-invasive biomarkers present in the serum of patients with CRC and, subsequently, to create a score capable of predicting the development of CRC.
It is an observational study with 3 enrollment arms:
Arm 1: Patients undergoing surgery at the U.O.C. of Surgery, with a CRC diagnosis;
Arm 2: Subjects with a negative result from the endoscopic examination;
Arm 3: Subjects in whom the presence of an adenoma with high-grade dysplasia is found, a condition considered pre-cancerous.
AIM 1: Patients undergoing surgery at the U.O.C. of Surgery, with a diagnosis of CRC.
AIM 2: Subjects without colon disease.
AIM 3: Subjects with adenoma and high-grade dysplasia.
Subject with any other pathology not included in the inclusion criteria.
The study cohort is comprised of patients with a diagnosis of CRC who underwent surgical intervention, and a cohort of subjects with high-grade dysplasia adenoma, which is considered a precancerous condition.
Other
Prospective
Not listed
Variation in serum biomarkers for CRC
Changes in the concentration of potential serum CRC biomarkers in patients with established CRC pre- and post-surgery, patients with an adenoma with high-grade dysplasia, and subjects with no evidence of disease.
Variation of macroconstituents
Variation in the macromolecule composition of biological samples.
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Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Lead sponsor
University of Bari Aldo Moro
Collaborator
