Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorStanford University
About this trial
The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and chemotherapy in head and neck and lung cancers. We have recently identified several proteins or markers in the blood and in tumors (including osteopontin, lysyl oxidase, macrophage inhibiting factor and proteomic technology) in the laboratory that may be able to identify tumors with low oxygen levels or more aggressive behaving tumors.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Histologically confirmed squamous cell carcinoma of the head and neck sites or non-small cell lung cancer, or relatives of patients with histologically confirmed squamous cell carcinoma of the head and neck.
Able to sign a Stanford IRB approved consent form
Disqualifiers
Refuse or unable to sign an IRB approved consent form.
Refuse to be contacted in the future for follow up.
Trial population
Newly diagnosed patients with head and neck cancer
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Tumor biopsy
Procedure/SurgeryFor patients who undergo tumor biopsy or resection at Stanford, approximately 500 mg of the tumor will be removed from the resection specimen
Phlebotomy
Procedure/SurgeryBlood draw (approximately 20 cc) prior to any anticancer therapy Weekly blood draw (approximately 20cc) only for patients who are undergoing radiation treatment at Stanford University
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Identification of Secreted Markers for Tumor Hypoxia through tissue collection
Time frame
before therapy, weekly during therapySponsors and contacts
Click on the lead sponsor to view all of their trials.
Stanford University
Lead sponsor
National Institutes of Health (NIH)
Collaborator
National Institute of Dental and Craniofacial Research (NIDCR)
Collaborator
Source ClinicalTrials.gov