Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversitätsklinikum Hamburg-Eppendorf
About this trial
The goal of this observational study is to
* to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; * to evaluate the influence of lesion location on autonomic dysfunction; * to identify patterns of structural and functional brain connectivity within the central autonomic control circuits associated with autonomic dysfunction; and * to explore causal models of the link between brain lesions; cardiac, immunological and endocrine biomarkers; and dysautonomia.
Researchers will compare patients with acute ischemic stroke to patients with transient ischemic attacks to study the effect of acute ischemic brain lesions.
Participants will
* undergo cardiovascular autonomic function testing; * receive structural and functional MR imaging; * provide blood samples for determinaton of serological biomarkers auf dysautonomia.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of either
acute ischemic stroke with either an ischemic lesion visible on CT/MRI or persistent focal deficits 24 hours after symptom onset, or
Transient ischemic attack with transient clinical deficits including motor or speech disturbance and not restricted to isolated vertigo/dizziness, visual disturbance, or sensory disturbance.
symptom onset within 72h prior to hospital admission,
Disqualifiers
In-hospital stroke,
contraindications to MR imaging (e.g., claustrophobia, pregnancy, pacemakers, implants),
known moderate to severe dementia,
previous structural brain damage (except leukoariosis due to cerebral small vessel disease),
Trial population
Patients will be recruited from the Stroke Unit at the Department of Neurology at University Medical Center Hamburg-Eppendorf
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Autonomic dysfunction
Cardiovagal and Adrenergic Scores on the Composite Autonomic Scoring Scale (0-7, higher values indicate greater dysfunction)
Time frame
3-5 days after stroke onsetSecondary outcomes
1
Autonomic dysfunction
Cardiovagal and Adrenergic Scores on the Composite Autonomic Scoring Scale (0-7, higher values indicate greater dysfunction)
Time frame
90 days after stroke onsetSponsors and contacts
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Source ClinicalTrials.gov