Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Pittsburgh
About this trial
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18-49
Right-handed
Native English speaker
Age 18 or older
Disqualifiers
Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
Trial design
Design model
Single group
Treatments tested in this trial
Neural responses to speech functional localizer
BehavioralMeasuring speech-related brain activity using fMRI during a speech listening task.
Neural responses to silent articulation
BehavioralMeasuring speech-related brain activity using fMRI during a silent articulation task.
Neural responses to self vs. externally generated speech
BehavioralMeasuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
Event-related potentials for speech
BehavioralMeasuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
Neural responses to induced speech errors
BehavioralMeasuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Neural responses to sensory-motor adaptation
BehavioralMeasuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
Speech production behaviors
BehavioralBehavioral measurements of speech during reading passages and words
Auditory acuity testing
BehavioralMeasurements of auditory acuity during listening tasks.
Neural responses to learning a non-speech auditory motor behavior
BehavioralMapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Speech behavior and functional imagingExperimental treatment 9 interventions
Trial outcomes
Primary outcomes
1
Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features.
Time frame
One session lasting 2-3 hours, within 12 months of enrollment2
BOLD responses related to pre-speech auditory modulation
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses to auditory stimuli across conditions (e.g., SPEAK, REHEARSE, PLAN, SILENT).
Time frame
One session lasting 2-3 hours, within 12 months of enrollment3
EEG responses to self vs. externally generated speech
The dependent variables are evoked responses, aligned to sound onset, measured with EEG during task performance. We will contrast evoked responses across conditions (e.g., TALK, LISTEN).
Time frame
One session lasting 2-3 hours, within 12 months of enrollment4
BOLD responses to induced auditory errors
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will determine activations in regions of interest that correlate with applied perturbations during speech. We will also compare SPEAK vs. LISTEN activations in perturbed and unperturbed conditions.
Time frame
One session lasting 2-3 hours, within 12 months of enrollmentSecondary outcomes
1
BOLD responses to speech listening task
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations for the SPEECH vs. signal correlated noise (SCN) and SPEECH vs. SILENT conditions.
Time frame
One session lasting 2-3 hours, within 12 months of enrollment2
BOLD responses to silent articulation task
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations for silent articulation vs. a resting baseline condition.
Time frame
One session lasting 2-3 hours, within 12 months of enrollment3
Speech formant frequencies
We will measure participant-specific phonetic variables (formant frequencies) based on participant speech from reading passages and word production.
Time frame
First session lasting 2-3 hours, within 12 months of enrollment4
Spontaneous Speech Synchronization Index
We will measure the Spontaneous Speech Synchronization Index based on behavioral speech data.
Time frame
First session lasting 2-3 hours, within 12 months of enrollmentSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Pittsburgh
Lead sponsor
Northwestern University
Collaborator
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator
Source ClinicalTrials.gov