IMAT Quality in Aging
ConditionAging
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-80
SponsorWashington University School of Medicine
About this trial
This study will test the central hypothesis that fat within the muscle, or intramuscular adipose tissue (IMAT), exhibits elevated damage and pro-inflammatory signaling with aging, both of which are reduced by progressive resistance exercise (PRE). Sixteen older adults 65-80 years old will be recruited and complete a 12 week calf PRE intervention. Calf muscle strength, composition (measured by computed tomography) and muscle biopsies will be collected before and after the intervention. Histology, transcriptomic and secretomic tests will be completed to assess signs of damage and inflammation.
Eligibility criteria
Qualifiers
Rapid Assessment of Physical Activity scores between 3 and 5
Able to don and doff the weighted vest
Access to a smart phone and ability to navigate the phone to enter and manage a zoom intervention
Commitment and availability to attend a virtual 40-minute intervention 3x per week for 12 weeks
Disqualifiers
Contraindications to radiation exposure (e.g. Women who are pregnant, previous high radiation exposure)
Bleeding disorders
Lower extremity trauma/surgery/injury or neuropathy that would impact muscle structure and function or ability to complete exercise intervention
Diabetes mellitus, cardiovascular disease, peripheral vascular disease, cancer, stage 4 hypertension, anemia, connective tissue disorder
Trial design
Treatments tested in this trial
- Calf muscle strengthening
Treatment groups
16 Participants
are divided into 1 treatment groupSponsors and collaborators
Washington University School of Medicine
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov