Immune Cell Response to Stimuli
ConditionInflammation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorNational Institute of Environmental Health Sciences (NIEHS)
About this trial
This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. It will determine how the cells may, under certain circumstances, contribute to inflammation, and will measure substances in the blood plasma (the liquid, non-cellular part of the blood) that might stimulate white blood cells, in order to understand how the blood responds to possible disease-related conditions.
Healthy normal volunteers 18 years of age and older who weigh at least 110 pounds may be eligible for this study. Participants give about 320 milliliters (mL) of blood (about 1 1/3 cups) or less at each donation. They donate no more than once every 8 weeks and no more than six times a year. On some occasions, less than 320 mL of blood may be drawn. The collected blood is separated into its components and specific cells are exposed to substances to examine their response.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Normal, healthy adult donors as judged by screening questionnaire
Nonpregnant
Weighing at least 110 lbs
18-65 years of age
Disqualifiers
Hematocrit less than 34% for women or less than 36% for men, or greater than 56% for either gender.
Patients will be informed of disqualifying vital signs and hematocrit values and advised by trained staff, as appropriate, to seek assistance from their physician.
Trial population
Any healthy donors meeting inclusion/exclusion criteria
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
750 Participants
are grouped into 1 trial groupGroup A: 1
Trial outcomes
Primary outcomes
1
The objective is to define the signaling pathways activated by lipopolysaccharide (LPS) and other selected innate immunity stimuli, and the downstream inflammatory functional consequences, in human leukocytes in vitro.
The objective is to define the signaling pathways activated by lipopolysaccharide (LPS) and other selected innate immunity stimuli, and the downstream inflammatory functional consequences, in human leukocytes in vitro.
Time frame
analysis of the studySponsors and contacts
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Source ClinicalTrials.gov