Immune Cells During Disuse and Recovery
ConditionMuscle Disuse
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorUniversity of Utah
About this trial
This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants. The study will occur over the course of 1-2 months where participants will undergo testing before and after a 2-week limb immobilization period.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age between 18-35 and 60-85 yrs
Ability to sign informed consent
Free-living, prior to admission
Disqualifiers
History of cardiovascular disease (e.g., CHF, CAD, right-to-left shunt)
History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes
History of kidney disease or failure
Vascular disease
Trial design
Design model
Single group
Treatments tested in this trial
Limb immobilization
Other interventionParticipants will undergo a 2-week period of leg immobilization
Treatment groups
45 Participants
are divided into 1 treatment groupGroup A: Limb immobilizationOther 1 intervention
Trial outcomes
Primary outcomes
1
Thigh Muscle Volume
change in thigh muscle volume as determined by MRI
Time frame
baseline and after 2 weeks of leg immobilization2
Leg Muscle Strength
change in isometric leg extension strength as determined by a isokinetic dynamometer
Time frame
baseline and after 2 weeks of leg immobilizationSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov