Immune Homeostasis in Sepsis and Septic Shock
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCharles University, Czech Republic
About this trial
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
sepsis/septic shock (SEPSIS-3)
age ≥18
informed consent
inclusion within first 24hrs after development/diagnosis of septic shock
Disqualifiers
disagreement of the patient or legal representative with the entry into the study
patients with primary or secondary immunodeficiency
presence of active haematological malignancy or an active non-haematological malignancy
Trial population
sepsis/septic shock according SEPSIS-3 definition
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
transcriptomics
Other interventiontranscriptomics
flow-cytometry
Other interventionperipheral blood myeloid cells and lymphocytes flow-cytometry
cytokines
Other interventionperipheral blood cytokine analysis
Treatment groups
200 Participants
are divided into 3 treatment groupsGroup A: sepsis/septic shock3 interventions
Group B: non-septic critically ill3 interventions
Group C: healthy control3 interventions
Trial outcomes
Primary outcomes
1
Immune response description - flow cytometry
Detailed description of immune response analyzed by mean of flow cytometry
Time frame
2024 - 20262
Immune response description - transcriptomics
Detailed description of immune response analyzed by mean of transcriptomic analysis
Time frame
2024 - 20263
Immune response description - ELISA
Detailed description of immune response analyzed by mean of ELISA
Time frame
2024 - 2026Secondary outcomes
1
Diagnostic "immune status" panel
Diagnostic tool for immune status assessment
Time frame
2026 - 2028Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov