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Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis

ConditionDown Syndrome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-6
SponsorBadr University

About this trial

Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Down Syndrome with acute bronchopneumonia

sufficient cognitive ability

Disqualifiers

severe congenital heart defects

primary immunodeficiencies

Trial population

Data collection occurred at the inpatient pediatric ward of King Abdulaziz University Hospital.

Trial design

Design model

Other

Time perspective

Retrospective

Treatments tested in this trial

  • Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age

    Procedure/Surgery

    Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

serum IgG, IgA, IgM

Immunoglobulins: Concentrations of IgG(mg/dl) IgA,(mg/dl) and IgM (mg/dl) were determined from serum using an automated nephelometer

Time frame
Upon enrollment and prior to any intervention baseline data were collected
2

Respiratory Rate

Respiratory rate (breaths/minute) was determined by direct observation and counting of chest wall movements over one full minute

Time frame
Upon enrollment and prior to any intervention baseline data were collected
3

Arterial Oxygen Saturation (SaO2)

Peripheral oxygen saturation (%) was measured non-invasively via pulse oximetry

Time frame
Upon enrollment and prior to any intervention baseline data were collected
4

White Blood Cell count

Total WBC count (thousands/mm³) was measured from a whole blood sample using an ADVIA 120 automated hematology analyzer

Time frame
Upon enrollment and prior to any intervention baseline data were collected

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Badr University

Lead sponsor

Source ClinicalTrials.gov
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