Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondation Ophtalmologique Adolphe de Rothschild

About this trial

The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC.

HD carried out in a context of acute cerebral haemorrhage

Pre-existing neurological disability: modified Rankin score > 2

Patient benefiting from a legal protection measure

Disqualifiers

None

Trial population

The target population concerns patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy. Eligibility will be assessed as soon as the first results of the MRI or brain scan carried out as part of the thrombolysis alert by the interventional neurologist or neuroradiologist triggering the treatment, in front of a large ischaemic cerebral accident (\>145 ml).

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Decompressive hemicraniectomy

    Procedure/Surgery

    Decompressive hemicraniectomy in the context of a malignat sylvian ischaemic cerebral accident

  • neurosurgical operation

    Procedure/Surgery

    neurosurgical operation on which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.

Treatment groups

90 Participants
are divided into 2 treatment groups
Group A: Experimental group1 intervention
Group B: Control group1 intervention

Trial outcomes

Primary outcomes

1

neutrophil polynuclear cells levels

Time frame
Day 0

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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