Immunological Mechanisms of Rejection in Uterine Transplantation
ConditionTransplant Rejection
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorHopital Foch
About this trial
The objective of this study is to understand the mechanisms of rejection in uterine transplantation and to search for non-invasive markers of rejection. The biological samples necessary for our research have been or will be collected during procedures (biopsies, smears, vaginal swab, blood tests) carried out as part of the scheduled follow-up of patients. These will be samples whose collection is minimally or not invasive
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient going to or having received a uterine transplant OR Patient going to or having donated a uterus for a recipient included in the study OR Premenopausal woman to undergo gynecological surgery under general anesthesia: for 4 of them it was a hysterectomy and they must be under 45 years old, the other 6 must be under 38 years old.
Disqualifiers
Pregnancy in progress
Current infection
Cervical dysplasia
History of transplant or transfusion
Trial design
Design model
Parallel
Treatments tested in this trial
Specimens
Other interventionSpecimens (blood, biopsy, cervical smear, vaginal swab)
Treatment groups
30 Participants
are divided into 3 treatment groupsGroup A: Graft recipientOther 1 intervention
Group B: Living donorOther 1 intervention
Group C: WitnessOther 1 intervention
Trial outcomes
Primary outcomes
1
presence of new markers associated with transplant rejection
Time frame
8 yearsSecondary outcomes
1
incidence of pregnancy on transplant immunology
Time frame
8 years2
microbiota in uterine transplant
Time frame
8 yearsSponsors and contacts
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Source ClinicalTrials.gov