Immunomodulatory Effects of Fasting in Healthy Adults
ConditionFasting
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-40
SponsorUniversity of California, Davis
About this trial
This is a clinical trial assessing the effects of fasting on the immune system in healthy adults. Immune profiling, gene expression profiling, and flow cytometry on peripheral blood mononuclear cells (PBMCs) will be performed and we hypothesize that a period of fasting will alter the immune system in healthy adults.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age: 20-40 years, to constitute a young study population
Gender: male subjects, to control for gender differences
BMI: 19-27 kg/m2 to constitute a normal/healthy weight population
Weight: 120 lbs or more
Disqualifiers
Current smoking
Anemia
Pregnancy or current breastfeeding
Chronic diseases including diabetes mellitus, thyroid disease, metabolic syndrome, cancer, or previous cardiovascular events
Trial design
Design model
Single group
Treatments tested in this trial
Dietary Fasting
BehavioralThe study will consist of two days of eating a "controlled habitual diet" and one 36-hour period of water-only fasting with glucose monitoring as a measure of compliance. Water intake will be limited to 2 liters/day to prevent electrolyte abnormalities. Subjects will undergo 4 separate blood-draws consisting of an overnight fasted sample (Baseline), a 2-hour postprandial sample (Fed), a 36-hour fasted sample (Fasted), and final 2-hour postprandial sample after the fasting period (Refed).
Treatment groups
4 Participants
are divided into 1 treatment groupGroup A: FastingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Changes in peripheral blood mononuclear cells
Changes in surface proteins and glycoproteins of peripheral blood mononuclear cells
Time frame
7 monthsSponsors and contacts
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Source ClinicalTrials.gov