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IMPACT: Immune and Musculoskeletal Physiological Adaptations to Combined Exercise Training & Nutrition

ConditionsOverweight (BMI > 25)Males and Females
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorYork University

About this trial

The purpose of this study is to determine whether 12 weeks of exercise training combined with dairy consumption influences inflammation and immune responses in adults with overweight, compared to exercise training alone.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Between the ages of 18 and 50 years

Overweight BMI (25.0-29.9) kg/m2

'Overweight' body fat percentage (males: ≤30%; females: ≤42%)

Low to moderately physically active (0-2 times/week)

Disqualifiers

Peri- or postmenopausal status (female)

Dairy protein allergy or lactose intolerance

Use of vitamin D and/or calcium supplements

Any musculoskeletal, autoimmune, or inflammatory conditions

Trial design

Design model

Parallel

Treatments tested in this trial

  • Milk

    Dietary supplement

    2 servings of 1% MF milk (1 serving = 250 mL) on non-training days and 3 servings on training days, integrated into habitual diet.

  • Greek Yogurt

    Dietary supplement

    2 servings of plain or flavoured GY (1 serving = 175 g) on non-training days, and 3 servings of GY on training days, integrated into your habitual diet.

  • Exercise training

    Behavioral

    12-week structured exercise training program. Exercise sessions will take place three times per week and will last approximately 60 minutes per session. Sessions will be conducted at York University in the Exercise Research Lab. Each session will be facilitated by a certified personal trainer and/or kinesiology student

Treatment groups

60 Participants
are divided into 3 treatment groups
Group A: Exercise alonePlacebo comparator 1 intervention
Group B: Exercise + MilkExperimental treatment 2 interventions
Group C: Exercise + Greek YogurtExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Inflammatory Cytokines assessed from blood samples via Elisa

e.g., Interleukin-6 (IL-6)

Time frame
week 0 and week 12
2

Body Composition determined via Bodpod

e.g., Lean mass

Time frame
week 0 and week 12
3

Bone turnover assessed from blood samples via Elisa

e.g., Procollagen type 1 N-propeptide (P1NP)

Time frame
week 0 and week 12

Secondary outcomes

1

Immune system function (ex vivo cellular leukocyte analyses) via flow cytometry

e.g., monocyte cell counts

Time frame
week 0 and week 12
2

Body Composition determined via Bodpod

Body fat mass

Time frame
week 0 and week 12
3

Body Composition determined via Bodpod

% body fat

Time frame
week 0 and week 12
4

Muscle thickness determined by ultrasound

Thickness and Cross-sectional area

Time frame
week 0 and week 12

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

York University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: