The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.
Incidentally detected adrenal mass
Patients with overt Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenocortical carcinoma, late-onset congenital adrenal hyperplasia, adrenal metastasis and adrenal hemorrhage
Patients taking medications influencing glucocorticoid production or metabolism
Patients with psychiatric diseases or alcohol abuse
Pregnancy
Patients with non-functioning adrenal incidentalomas or adrenal incidentalomas associated with possible autonomous cortisol secretion (subclinical hypercortisolism)
Case-control
Prospective
Adrenalectomy
Procedure/SurgeryAdrenalectomy according to 2016 ESE guidelines
Echocardiographic Change of Left Ventricular Hypertrophy
Change of Left Ventricular Hypertrophy will be evaluated by transthoracic echocardiography. Patients will be examined in the left lateral decubitus position according to the American Society of Echocardiography guidelines.
Change of arterial stiffness and blood pressure using brachial oscillometric blood pressure waves for a noninvasive estimation.
Perform non-invasive measurement of arterial stiffness
Change of blood pressure using ambulatory blood pressure monitoring blood pressure waves for a noninvasive estimation.
Perform twenty-four-hour systolic and diastolic ambulatory blood pressure monitoring
Change in blood Coagulation Tests
Perform blood sampling for coagulative function
Change in Dual X-Ray Absorptiometry T-score
Bone mineral density change in spine and femur
Click on the lead sponsor to view all of their trials.
