KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill. In some cases, the kidneys may temporarily stop working in very sick patients, and machines are used to filter the blood. This study is exploring whether the way the investigators use these machines - how early to start, how much treatment to give, and what type to choose - makes a difference in how well the kidneys recover. By learning from many hospitals and hundreds of patients, KARMA hopes to improve treatment choices and help patients regain their kidney function faster.
Acute kidney injury
ICU administration
Pre-existing CKD (GFR < 30 ml/min/1,73m2)
Chronic dialysis-dependent end-stage renal failure
By analyzing the variation in therapeutic approaches across centers-including convection- and diffusion-based techniques, dose intensity, and initiation thresholds-KARMA study aims to identify best practices that promote renal recovery and reduce the transition to acute kidney disease. The study integrates clinical, biochemical, and outcome metrics to support a precision medicine framework in critical care nephrology and in critically ill patients with acute kidney injury.
Cohort
Retrospective
Continuos renal replacement therapy
DeviceDifferent modalities of CRRT: continuous veno-venous hemofiltration; continuous veno-venous hemodialysis and continuous veno-venous hemodiafiltration Different doses of CRRT: low effluent dose (\<15 ml/kg/h); medium-low effluent dose (15-25 ml/kg/h); standard effluent dose (25-30 ml/kg/h); high effluent dose (\>30 ml/kg/h
Percentage of patients with AKD
Percentage of patients with AKD divided by subgroups regarding AKI etiology
Durations and severity of AKD, free days of CRRT and kidney recovery
AKD duration in days AKD severity described and compared by AKI stages Patients with AKD divided by subgroups regarding indication for CRRT (fluid overload, electrolyte disturbances, metabolic acidosis, uremia, oliguria/anuria) and CRRT dose (ml/kg/hour) CRRT free days during ICU Kidney recovery/stage of CKD/dialysis dependency
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This trial is not recruiting at the moment. You can still explore other options:
