Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age15-18
SponsorUniversity of Electronic Science and Technology of China

About this trial

Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

15-18 years

right-handed

normal or corrected normal visual acuity

meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)

Disqualifiers

diagnosis of borderline personality disorder, major depressive disorder, other

psychiatric disorders, etc.

high suicidal risk

recent use of medications that can affect neural activity

Trial population

Treatment-seeking NSSI individuals will be recruited from local hospitals and HC from the community.

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

80 Participants
are grouped into 2 trial groups
Group A: NSSI
Group B: HC

Trial outcomes

Primary outcomes

1

Reward prediction errors (PEs)

Reward PEs will be calculated by the differences between the experienced (when be offered) reward and predicted (before the offer) reward.

Time frame
About 20 minutes
2

Valence prediction errors (PEs)

Valence PEs will be calculated by the differences between the experienced emotional valence and predicted emotional valence.

Time frame
About 20 minutes
3

Arousal prediction errors (PEs)

Arousal PEs will be calculated by the differences between the experienced emotional arousal and predicted emotional arousal.

Time frame
About 20 minutes
4

The prediction of PEs of punishment decisions

All PEs and groups (NSSI, HC) will be used in a regression model to examined whether there is any alteration in the NSSI group when PEs are predicted to punishment (reject) decisions.

Time frame
About 20 minutes

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.