Multicenter prospective observational cohort study, comparing ongoing pregnancy rates in natural cycles for euploid embryo transfer in patients who present endometrial compaction at the time of the transfer versus those who have a stable or greater endometrial thickness with respect to the estrogenic phase.
Aged 18 to 50 years
Primary or secondary infertility
Normal uterine cavity
Endometrial preparation in a modified natural cycle for single embryo transfer
Uterine or endometrial disease (multiple myomatosis [>3 fibroids of > 3 cm], adenomyosis, Asherman syndrome)
Difficulties in correctly measuring endometrial thickness due to a retroverted or tilted uterus
History of recurrent implantation failure (3 or more transferred blastocysts of good quality, from their own oocyte [<35 years] or oocyte donation); recurrent early Pregnancy Loss (the loss of two or more pregnancies before 10 weeks of gestational age.
Suboptimal endometrial response (endometrium < 6 mm on the day of ovulation triggering).
206 Women between 18-50 years, with primary or secondary infertility, undergoing fertility treatment that includes endometrial preparation in a modified natural cycle for transfer of previously analyzed frozen and euploid embryos.
Cohort
Prospective
Observational non intervention study
Other interventionAn additional control scan will be performed vaginally the day of the embryo transfer. Rest of follow up and treatment will be executed as usually.
Ongoing pregnancy rate
Presence of an intrauterine pregnancy with positive embryo heartbeat as seen by sonography at 8-10 weeks gestational age.
Biochemical pregnancy loss
Spontaneous pregnancy demise based on decreasing serum b-hCG levels, without an ultrasound evaluation.
Clinical pregnancy
A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy.
Ectopic pregnancy
ultrasonic or surgical visualization of a pregnancy outside of the endometrial cavity.
Early pregnancy loss
spontaneous pregnancy demise before 10 weeks of gestational age (before 8th developmental week).
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Instituto Bernabeu
Lead sponsor
Universidad Miguel Hernandez de Elche
Collaborator
