Impact of Estimated Concentration of Propofol on Implicit Memory Formation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-90
SponsorUniversity of Padova
About this trial
Implicit memory formation and learning during general anaesthesia is a still debated question and no anesthetic regimen (ie intravenous anaesthesia vs inhalatory one) nor analgesic regimen (i.e. low or high opioids usage) has been identified for prevention.
With this study the investigators aim to investigate if, during Total Intravenous Anaesthesia with Target Controlled Infusion (TIVA-TCI) different concentrations of Propofol at loss of responsiveness, maintenance and return of responsiveness can have a role in implicit memory formation.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
General anaesthesia with TIVA-TCI
Disqualifiers
ASA > III
Benzodiazepines premedication
Neurological/Psychiatric disease
Trial population
Breast-Surgery women undergoing TIVA-TCI
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
80 Participants
are grouped into 2 trial groupsGroup A: Cases
Group B: Controls
Trial outcomes
Primary outcomes
1
The role of Propofol Concentration at the loss of responsiveness on Implicit Memory formation
CeP at LOR will be compared between patients who exhibit or not implicit memory formation.
Time frame
CeP will be recorded at Loss of responsiveness. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.2
The role of Propofol Concentration at the maintenance of anaesthesia on Implicit Memory formation
CeP at anaesthesia maintenance will be compared between patients who exhibit or not implicit memory formation.
Time frame
CeP will be recorded during anaesthesia maintenance. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.3
The role of Propofol Concentration at the return of responsiveness on Implicit Memory formation
CeP at ROR will be compared between patients who exhibit or not implicit memory formation.
Time frame
CeP will be recorded at Return of responsiveness. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.Sponsors and contacts
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Source ClinicalTrials.gov