Lipid restriction is significant in anorexia nervosa and limits therapeutic management. The multisensory perception of fat is altered, creating an aversion to lipids. The investigators aim to characterize the impact of sensory stimulation (smells or images) associated with specific tastes using neuropsychological assessments and functional MRI. Some volatile aromas can enhance the perception of the associated taste. The investigators hypothesize that such associations are altered in anorexia nervosa for fatty foods but may be preserved for sweet tastes, and that this alteration contributes to the maintenance of the disease. The interdependence of different sensory perceptions of lipids could play a major role in the therapeutic approach, aiding in the deconditioning of this aversion and the restoration of positive food sensory associations.
Person affiliated or entitled to a social security scheme
Person having received informed information on the study and having co-signed, with the investigator, a consent to participate in the study
female person
Person affiliated or entitled to a social security scheme
Pregnant women, parturient, nursing mothers;
Persons deprived of their liberty, hospitalized without consent, hospitalized for purposes other than research;
Minors
Refusal of the study by the participant
Parallel
MRI examination
Other interventionOne hour MRI examination
Smell and taste capacity testings
Other interventionone hour sensory testings
Brain activity measured by functional MRI
Estimation of the "fatty vs. neutral" contrast when all three senses are used, comparing AN patients to the normal-weight control group (NC group) in each voxel of the brain volume (whole-brain analysis) and in the orbitofrontal cortex (ROI analysis).
Brain activity measured by functional MRI
Estimation of the "fatty vs. neutral" contrast when all three senses are used, comparing AN patients to the control group with a similar BMI (CT group) in each voxel of the brain volume (whole-brain analysis) and in the orbitofrontal cortex (ROI analysis).
Brain activity measured by functional MRI
BOLD signal variations between the groups (AN, NC, and CT) for the "sweet vs. neutral" contrast.
Brain activity measured by functional MRI
BOLD signal variations for single vs. three senses simultaneously for each group and between groups for the "fatty vs. neutral" and "sweet vs. neutral" contrasts.
BMI
Body Mass Index
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