Impact of Iron Deficiency on Arrhythmic Events and Resting ECG Abnormalities in Patients Hospitalized With Heart Failure
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
The relationship between iron deficiency (with or without anemia) and arrhythmic risk or ECG abnormalities in hospitalized HF patients remains poorly characterized. This is particularly relevant in settings where advanced iron therapies (e.g., intravenous iron supplementation) may not be readily available, and where simple clinical and electrocardiographic markers could help identify high-risk patients by evaluating the impact of iron deficiency (with and without anemia) arrhythmic events and resting ECG changes among patients admitted with heart failure. Understanding these associations may offer insights into the arrhythmogenic potential of iron deficiency and support the integration of iron status assessment into routine risk stratification and management of HF patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Adult patients (≥18 years) admitted with heart failure over a period of one year at Assiut University Heart Hospital (AUHH)
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Incidence of anemia and iron deficiency in hospitalized patients with HF
The proportion of patients admitted with heart failure who are found to have anemia and/or iron deficiency during hospitalization. Anemia is defined according to WHO criteria (Hb \<13 g/dL in men, \<12 g/dL in women). Iron deficiency is defined as ferritin \<100 ng/mL, or ferritin 100-299 ng/mL with transferrin saturation \<20%.
Time frame
through study completion, an average of 1 year2
Incidence of arrhythmic events in hospitalized HF patients with and without iron deficiency possible
The proportion of hospitalized heart failure patients who experience arrhythmic events (such as atrial fibrillation, ventricular tachycardia, ventricular fibrillation, or clinically significant bradyarrhythmias) during admission. Patients will be categorized based on the presence or absence of iron deficiency (defined by ferritin \<100 ng/mL, or ferritin 100-299 ng/mL with transferrin saturation \<20%).
Time frame
through study completion, an average of 1 yearSecondary outcomes
1
Resting ECG abnormalities in hospitalized HF patients with and without iron deficiency
The prevalence and types of resting ECG abnormalities (e.g., atrial fibrillation/flutter, QRS prolongation \>120 ms, ST-T changes, pathological Q waves, left ventricular hypertrophy, bundle branch blocks, premature ventricular complexes) in hospitalized heart failure patients. Patients will be stratified according to the presence or absence of iron deficiency (defined as ferritin \<100 ng/mL, or ferritin 100-299 ng/mL with transferrin saturation \<20%).
Time frame
through study completion, an average of 1 year2
Correlation between iron parameters, anemia status, and resting electrophysiologic parameters on 12-lead ECG
This outcome evaluates the correlation between iron status indicators (serum ferritin, transferrin saturation, and serum iron levels) and anemia-defined according to WHO criteria (hemoglobin \<13 g/dL in men, \<12 g/dL in women)-with resting electrophysiologic parameters obtained from a standard 12-lead ECG. Each electrophysiologic parameter will be correlated separately with continuous iron and hemoglobin values
Time frame
through study completion, an average of 1 year3
Association between iron parameters (and anemia) and electrophysiologic parameters
Assessment of the relationship between iron status (ferritin, transferrin saturation, serum iron) and anemia (defined by WHO criteria: Hb \<13 g/dL in men, \<12 g/dL in women) with resting electrophysiologic parameters on 12-lead ECG. Parameters include: Rhythm: sinus rhythm, atrial fibrillation/flutter, ventricular arrhythmias Conduction: PR interval, QRS duration, bundle branch block Repolarization: QT/QTc interval, ST-T abnormalities Heart rate variability (if available) Patients will be stratified according to presence/absence of iron deficiency and anemia, and correlations will be examined between continuous iron parameters and ECG metrics.
Time frame
through study completion, an average of 1 yearLocations
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Source ClinicalTrials.gov
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