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Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy

ConditionsIsofluraneSevofluraneOxidative StressLaparoscopic Cholecystectomy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-60
SponsorAin Shams University

About this trial

The primary aim of this work is to assess the impact of exposure to isoflurane or sevoflurane as an inhalation anesthetic on the oxidative stress and inflammatory conditions in patients undergoing elective moderate invasive surgery (laparoscopic cholecystectomy).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 20 to 60 years.

Both sexes.

American Society of Anesthesiologists (ASA) Physical Status I-II.

Undergoing elective laparoscopic cholecystectomy under general anesthesia.

Disqualifiers

Refusal of participation in the study by patients.

Diabetes (type I or II), endocrine system, and immune system diseases.

Chronic infection and sepsis.

Cardiac condition as classified bythe New York Heart Association (NYHA) > class II.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Isoflurane

    Drug

    Patients will receive general anesthesia and maintenance by isoflurane.

  • Sevoflurane

    Drug

    Patients will receive general anesthesia and maintenance by sevoflurane.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Group IsoExperimental treatment 1 intervention
Group B: Group SevExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Serum level of superoxide dismutase

Serum level of superoxide dismutase (SOD) will be recorded.

Time frame
6 months postoperatively

Secondary outcomes

1

Serum level of serum soluble programmed cell death-ligand 1

Serum level of serum soluble programmed cell death-ligand 1 (sPD-L1) will be recorded.

Time frame
6 months postoperatively
2

Serum level of nuclear factor erythroid 2-related factor

Serum level of nuclear factor erythroid 2-related factor (Nrf2) will be recorded.

Time frame
6 months postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ain Shams University

Lead sponsor

Source ClinicalTrials.gov
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