Sickle cell disease is a chronic disease characterized by multiple vaso-occlusive complications. The basic treatment for patients with a vaso-occlusive crisis (VOC) is based on adequate hydration, oxygen therapy and pain control. Loco Regional Anesthesia (LRA) is one of the major treatments in resuscitation anesthesia for both anesthesia and analgesia. LRA allows effective and almost immediate pain control by blocking nerve afferents in a given area. LRA could decrease the inflammatory response during crises and accelerate resolution of the crisis.
patients adult >18 years
patients with vaso-occlusive crisis
Pregnant or breastfeeding women
Blood transfusion within the last 3 months
Lack of affiliation with the French social security system
Protected individuals
Adult sickle cell patients consulting for vaso-occlusive crisis in CHU de Guadeloupe
Case-only
Prospective
Not listed
Inflammatory process during vaso-occlusive crises
The variation between D0 and D1 in the proportion of endothelial cells expressing ICAM-1 on their surface, following stimulation with microparticles from patients who received or did not receive regional anesthesia.
Quantification of protein levels
ICAM-1, VCAM-1, P-selectin, Elastase (marker of neutrophil extracellular traps (NET)
Quantification of cytokine levels
Quantification of cytokine levels
Quantitative and qualitative profil of blood microparticles
Quantitative and qualitative profil of blood microparticles
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