Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy
ConditionReproductive Issues
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-42
SponsorChinese University of Hong Kong
About this trial
Hypotheses:
We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.
Aims:
To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT).
Primary outcome:
To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer
Secondary outcomes:
Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients undergoing FET cycles
Infertility patients aged >18 years old and < 42 years old
BMI < 30 kg/m2
Transfer of at least one good-quality embryo.
Disqualifiers
Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)
Trial population
All infertility patients undergoing FET at the Assisted Reproductive Technology Unit of the department of Obstetrics and Gynecology in the Prince of Wales Hospital
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Clinical pregnancy rate (CPR)
Rate of clinical pregnancy outcome in subjects undergoing FET
Time frame
6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FETSecondary outcomes
1
Biochemical pregnancy rate
Rate of biochemical pregnancy outcome in subjects undergoing FET
Time frame
Up to 12 weeks2
Implantation rate
Rate of implantation in subjects undergoing FET
Time frame
Up to 12 weeks3
Early pregnancy loss rate
Rate of early pregnancy loss in subjects undergoing FET
Time frame
Up to 12 weeks4
Ectopic pregnancy rate
Rate of Ectopic pregnancy in subjects undergoing FET
Time frame
Up to 12 weeksSponsors and contacts
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Source ClinicalTrials.gov