Impact of Subthalamic Nucleus Deep Brain Stimulation on COGnitive and PSYchiatric Symptoms in Parkinson's Disease

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorInsel Gruppe AG, University Hospital Bern

About this trial

With this study, the investigators want to investigate how deep brain stimulation (DBS) affects various cognitive and psychiatric symptoms of Parkinson's disease (PD). In particular, they will examine whether stimulation of the left hemisphere has a different effect than stimulation of the right hemisphere on cognitive and psychiatric symptoms.

Eligibility criteria

Qualifiers

Diagnosed with Parkinson's disease

Treated with subthalamic nucleus deep brain stimulation (STN-DBS)

For part I: General research consent for the analysis of routine clinical data

For part II of the study: ability to provide informed consent

Disqualifiers

Atypical Parkinsonism

Other disease affecting the brain (e.g. Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, non-provoked epilepsy, brain tumour, etc.)

Haemorrhage during implantation of STN-DBS, which resulted in permanent cognitive or physical impairment

Schizophrenia, ongoing substance abuse, bipolar disorder or autism

Trial design

Treatments tested in this trial

  • DBS OFF state for left hemisphere
  • DBS OFF state for right hemisphere

Treatment groups

20 Participants
are divided into 2 treatment groups