This study aims to investigate the microbiome of women with previously proven fertility who plan to become pregnant.
Women with a previous live birth in the past 5 years and planning a new pregnancy with the same male partner.
18-40 years of age
Swedish personal identity number and a Swedish address (to send a sampling self-kit)
Sufficient understanding of spoken and written Swedish or English to provide informed consent and complete the web-based questionnaire.
Women who do not have a child yet and plan to cease their contraception.
Women with previously proven fertility who plan to become pregnant. The women will be recruited at the time of removal of a copper or hormonal intrauterine device (IUD) or removal of a contraceptive implant
Cohort
Prospective
Vaginal and rectal microbiome and metabolome
Diagnostic testVaginal- and rectal sampling as a self-kit will be taken by the pat when ceasing the contraception at the midwife clinic when confirmed a clinical pregnancy and if a miscarriage occurs. If a miscarriage occurs additionally to the self-kit an endometrial biopsy will be taken.
The microbiome profile and metabolome associated with time to pregnancy, miscarriage, and live birth will be assessed.
Microbiome profiles and metabolome related to obstetric outcomes
The microbiome profile for women above age >38 and women below <38.
The influence of BMI, medications and comorbidities on the microbiome profiles.
Microbiome profile for those women who don't conceive within a year.
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Karolinska Institutet
Lead sponsor
Karolinska University Hospital
Collaborator
