This project aims to study the effects of different types of thyroid surgery and RAIT on ovarian function and pregnancy outcomes of DTC women of childbearing age, analyze possible risk factors, and assess whether potential risk factors such as age, thyroid stimulating hormone (TSH) levels and positive thyroid antibodies are related to ovarian hypofunction and adverse pregnancy outcomes.
Age 20-45 years old;
Premenopausal women whose thyroid B-ultrasound + surgical pathology is clearly differentiated thyroid cancer (papillar thyroid cancer or follicular thyroid cancer);
TNM stage is in stage I (T1-3, N0 or N1, M0);
Treatment of thyroid tumor resection: unilateral lobe of the thyroid + isthmus resection, total thyroidectomy, total thyroidectomy + RAIT.
Patients with malignant tumors in other parts or low undifferentiated thyroid cancer;
Patients with abnormal liver and kidney function;
TNM stage II and above;
History of ovarian surgery, hysterectomy, pelvic surgery or radiation therapy;
Parallel
Total thyroidectomy
Procedure/SurgeryTotal thyroidectomy
Total thyroidectomy + RAIT
Procedure/SurgeryTotal thyroidectomy + RAIT
Thyroid one-sided lobe + isthmus resection
Procedure/SurgeryThyroid one-sided lobe + isthmus resection
AMH level
Measure the concentration of AMH in serum
Thyroid function
Measure the level of TSH、T3、T4、FT3、FT4、TGAB、TPOAB in serum
clinical pregnancy rate
Clinical pregnancy is defined as the detection of intrauterine gestational sac through ultrasound, and the clinical pregnancy rate is calculated by clinically pregnant women/total women.
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This trial is not recruiting at the moment. You can still explore other options:
